Charles River has extensive experience working with immunohistochemistry procedures, as well as with a broad range of tissue-based biomarkers. In addition, we can develop new procedures to assist you in answering specific questions regarding the activity of your test materials. Interpretation of specimens can be performed subjectively by a pathologist, or advanced quantifiable techniques can be applied.
Among our experience and offerings:
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Preclinical safety assessment for approximately 50-60 humanized, chimeric or murine monoclonal antibodies annually
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Experience with unconjugated antibodies, antibodies conjugated to a variety of substances and Fab fragments
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Techniques to reduce or eliminate the binding of secondary reagents to endogenous immunoglobulin to allow efficient and specific detection of bound unconjugated IgGs, particularly IgG1, even when the tissue is of the same species as the immunoglobulin