Neuropathology

Charles River combines experienced pathologists with a highly trained technical staff and well-designed laboratories to offer pathology services in the specialized area of neuropathology. We provide assistance in study design, development strategies and regulatory submissions for a wide variety of compounds affecting the nervous system. Each year, our scientists conduct over 30 GLP-compliant neuropathology studies in support of FDA and EPA regulatory submissions.

Services

  • Whole-body perfusion

  • Specialized nerve tissue embedding

  • Specialized staining capabilities

  • Electron microscopy (transmission electron microscopy and scanning electron microscopy)

  • Morphometric analysis

  • Immunohistochemistry

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Neurotoxicology Studies

Our scientists routinely perform neurotoxicity screening tests for possible on- or off-target effects, specialized target tissue delivery, expanded investigative studies and developmental neurotoxicity.

The Source℠

Download our datasheet on neuropathology on The Source℠, our secure portal for direct access to technical, scientific and educational resources.

Therapeutic Area: CNS

From animal models of disease to preclinical testing, we have developed the tools to assist clients in shortening the development cycle of compounds with neurological implications.