Musculoskeletal Toxicology

Charles River offers a fully integrated service with a team of scientists, pathologists, veterinarians and surgeons in the field of musculoskeletal research. Our team can assess the safety and efficacy of drugs and devices that have an intentional or unintentional effect on the musculoskeletal system.

This integrated approach allows the comprehensive evaluation of bone and cartilage drug efficacy, musculoskeletal tissue healing and biocompatibility, orthopedic device efficacy and the effects of new orthobiologic applications.

For our musculoskeletal research capabilities datasheet and Researcher newsletters, visit the Source.

  • Gonadectomy (ovariectomy and orchiectomy)-induced bone loss for osteoporosis drug testing
  • 5/6 nephrectomy model
  • TPTx (thyroparathyroidectomy) model
  • Schenk model in weanling rats (screen for anti-resorptive agents)
  • Bone defect models
  • Orthopedic models
  • Osteoarthritis models
  • Rheumatoid arthritis models

Note: Non-GLP efficacy models are also available for your early research.

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