DART

Charles River offers overall developmental and reproductive toxicology (DART) program planning and individual study design to conduct safety assessments for your products according to internationally recognized guidelines, including ICH and OECD.

We conduct male and female fertility, developmental toxicity (embryo-fetal development), pre- and postnatal development and multigenerational studies to assess the potential effects of pharmaceuticals, biopharmaceuticals and/or chemicals on the entire reproduction spectrum. A full range of rodent and nonrodent species are tested with dose routes ranging from dermal to intravenous infusion. A range of specialized functional evaluations is also available, including neurobehavioral testing and immunologic assays.

For additional information on our DART capabilities, including Researcher newsletters, webinars and historical control data, visit the Source℠.

  • Developmental and reproductive pathology
  • Specialized neurobehavioral testing
  • Functional assessments, including growth (and the skeleton), pulmonary, neurobehavioral, reproductive and immunological development
  • Toxicokinetic evaluations, including induction studies
  • Juvenile toxicity testing in rodents and nonrodent species
  • Hormone assays
  • Male reproductive assessments in rodents and nonrodents
  • Variety of behavioral tests (e.g., activity and learning and memory) for pre- and postnatal and multigenerational studies
  • Range of developmental immunology tests that can be added to pre- and postnatal and multigenerational studies
  • Endocrine disruptor assessments (uterotrophic assay and Hershberger assay)
  • Skeletal measurements (e.g., bone size, geometry and density) for pre- and postnatal studies using micro-CT, pQCT, X-ray and DXA

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Historical Control Data

Access the SourceSM, for information on our DART capabilities, including historical control data.

Zebrafish Teratogenicity Testing

This paper, co-authored by Charles River scientists, presents procedures for the basic care of a zebrafish colony to support embryo production, embryo collection and culturing, and teratogenicity experiments.

Immunology

Our labs conduct GLP-compliant immunotoxicology assessments in multiple species.