Developmental and Reproductive Toxicology (DART)

Charles River offers overall developmental and reproductive toxicology (DART) program planning and individual study design to conduct safety assessments for your products according to internationally recognized guidelines, including ICH and OECD.

DART & Juvenile Toxicology Resource Center

We conduct male and female fertility, developmental toxicity (embryo-fetal development), pre- and postnatal development and multigenerational studies to assess the potential effects of novel products on the entire reproductive spectrum. Our expertise includes pharmaceuticals (including vaccines, biopharmaceuticals, and veterinary and medical devices) agrochemicals, industrial chemicals and food additives. Our multigenerational study portfolio now includes the Extended One-Generation Reproductive Toxicity Study, required to satisfy OECD Guideline 443.

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Thyroid Hormone Analysis in Late-Fetal and Early-Neonatal Rat Samples*

We now offer an LC-MS/MS method for T3 and T4 with pg/mL lower limits of quantitation. (*Available in the SourceSM)

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A full range of rodent and nonrodent species are tested with dose routes ranging from dermal to intravenous infusion. A range of specialized functional evaluations is also available, including neurobehavioral testing and immunologic assays. All studies are supported by our own laboratory and regulatory experts.

For additional information on our DART testing capabilities, including juvenile toxicology, other Researcher newsletters, webinars and access to our extensive historical control data, visit the Source.

  • Hormone assays
  • Male reproductive assessments in rodents and nonrodents
  • Variety of behavioral tests (e.g., activity and learning and memory) for pre- and postnatal and multigenerational studies
  • Range of developmental immunology tests that can be added to pre- and postnatal and multigenerational studies
  • Endocrine disruptor screenings (in vivo and in vitro)
  • Skeletal measurements (e.g., bone size, geometry and density) for pre- and postnatal studies using micro-CT, pQCT, X-ray and DXA

For a full list of functional evaluations, view our Specialty Endpoints in Developmental and Reproductive Toxicology (DART) Technical Sheet*. (*Available in the Source)

You may also be interested in...

Webinar Replay

View our webinar “The Use of Microsampling to Improve the Relevance of Toxicity Study Data.”

Microsamples: When Less is More

Consider your sample size prior to moving into the preclinical phase, and reap big benefits further down your program timeline.

SOT Scientific Posters

Our DART scientists were in Baltimore in March presenting posters at SOT 2017. Download them via the Source.

ACT Scientific Poster

Presented at ACT, download our scientific poster, "Prenatal and Early Postnatal Development of the Thyroid Gland in the Rat."