Charles River offers overall developmental and reproductive toxicology (DART) program planning and individual study design to conduct safety assessments for your products according to internationally recognized guidelines, including ICH and OECD.
DART & Juvenile Toxicology Resource Center
We conduct male and female fertility, developmental toxicity (embryo-fetal development), pre- and postnatal development and multigenerational studies to assess the potential effects of novel products on the entire reproductive spectrum. Our expertise includes pharmaceuticals (including vaccines, biopharmaceuticals, and veterinary and medical devices) agrochemicals, industrial chemicals and food additives. Our multigenerational study portfolio now includes the Extended One-Generation Reproductive Toxicity Study, required to satisfy OECD Guideline 443.
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A full range of rodent and nonrodent species are tested with dose routes ranging from dermal to intravenous infusion. A range of specialized functional evaluations is also available, including neurobehavioral testing and immunologic assays. All studies are supported by our own laboratory and regulatory experts.
For additional information on our DART testing capabilities, including juvenile toxicology, other Researcher newsletters, webinars and access to our extensive historical control data, visit the Source℠.