General Toxicology

Charles River performs general toxicology safety evaluation studies for the pharmaceutical, chemical, agrochemical and consumer product industries. Our wealth of knowledge allows us to advise and conduct standard and novel toxicology study designs as well as deal with unexpected findings or toxicity issues during the course of a program.

Our carcinogenicity toxicology studies in rodents and toxicity studies in both rodent and nonrodent species are performed in full compliance with Good Laboratory Practice (GLP) regulations. In addition, all protocols are designed to meet the regulatory requirements of the various countries in which the products are to enter clinical trials or be marketed.

Access the SourceSM for additional information on our dermal services and minipig toxicology.

  • Dermal
  • Intra-articular
  • Intranasal
  • Intravaginal and intrapenile
  • Ocular
  • Oral (gavage, diet and capsule)
  • Parenteral (intravenous, subcutaneous, intradermal, intramuscular and intraperitoneal)
  • Rectal

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Keeping an Eye on Ocular Toxicity

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IND Program

We offer a highly cost-effective IND program for our clients.

Standard for Exchange of Nonclinical Data

Under the current timeline, within the next two to three years, any company or organization collecting, exchanging and submitting nonclinical data to the FDA will be required to adhere to SEND guidelines and regulations.