Charles River scientists pioneered the quantitative study of cutaneous phototoxicity by designing instruments, techniques and protocols now accepted as industry standards, and then extended these technologies to ocular phototoxicity and other specialty areas. We have a solid knowledge of different light sources and use industry-standard calibrated and validated spectroradiometric and radiometric monitoring instrumentation. This expertise fits with our experience of animal and in vitro models, allowing us to provide phototoxicology study designs that meet both standard and specialized requirements, with the assurance that the light quality and quantity is accurate and repeatable, regardless of the source.

  • Cytotoxicity endpoints in cell lines or hepatocytes
  • In vitro 3T3 NRU phototoxicity assay (OECD 432; ICH S10)
  • In vitro phototoxicity in the human reconstructed skin model Epiderm (ICH S10)
  • Photo Ames assay
  • Melanin Binding assay (ICH S10)
  • In vitro drug screening, development and safety testing
  • Regulatory experience in the phototoxicology field
  • Qualitative and quantitative phototoxicology in mice, rats and guinea pigs
  • Photoallergy studies, including photoactivated sensitizers
  • Safety assessment of photodynamic drugs
  • Safety assessment of unique light sources
  • Expertise in ocular phototoxicity in rats and rabbits
    • Board-certified veterinary ophthalmologists
    • Experienced ophthalmic pathologists
  • Light exposure (UVR, visible, near-infrared) under surgical conditions
  • Assessment of potential damage to thoracic and abdominal organs

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Expertise in pharmaceuticals, biologics, medical devices, veterinary medicines and agrochemicals.

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This work was initiated to evaluate the UVB sensitivity of the 3T3 cell line and whether the assay can be successfully employed to evaluate the phototoxic potential of test materials that absorb in the UVB region of the spectrum.

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