Surgical Models

Charles River offers a range of acute and chronic surgical models for use in any drug metabolism, pharmacology or safety study type. Our research surgeons have extensive experience in the development of sophisticated surgical procedures in a variety of rodent and large animal species and are available to assist in the creation of the most relevant animal model for an enhanced understanding of your compound.

Surgical Models

  • Vascular access ports
  • Bile duct cannulation
  • Enterohepatic recycling
  • Portal vein/intestinal cannulation
  • Carotid, jugular and femoral cannulations
  • Lymph, urine and cerebral spinal fluid
  • Intraduodenal, intrajejunal, intraileal and intracolonic

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Infusion Toxicology Studies

We conduct continuous intravenous infusion studies up to 6 months in most species and 12 months in selected animals.

surgeon performing surgical procedure

Rodent Surgery

We have specialized skills and resources to tailor research models to your specific needs.

foot bones

Bone Research

We offer a fully integrated service with a team of surgeons in the field of bone research.

ADME Studies

We conduct a range of
in vivo
metabolism studies in support of lead candidate selection, preclinical testing and clinical development programs.