Charles River provides bioanalytical support for samples generated in toxicology studies, and the resultant test article/item concentration data can be interpreted by our pharmacokinetics staff utilizing industry-standard WinNonlin® software using noncompartmental and compartmental approaches. We offer this as an integrated service, where all aspects of the study are managed within our laboratories, or as a stand-alone service, which enables analysis of concentration data generated elsewhere by the sponsor.

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Toxicokinetic parameter estimation output includes a comprehensive interpretation of the data, as required. In addition, we can address preclinical-to-clinical considerations (e.g., allometric scaling) when planning first-in-human studies.

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Charles River can develop, validate and apply quantitative bioanalytical methods for small molecules and larger proteins.

Toxicology Studies

Leading the industry in the fields of reproductive toxicology, inhalation, infusion, bone research and other specialty toxicological assessments.