Infusion Toxicology

Charles River has decades of experience in the conduct of safety and efficacy studies utilizing infusion dosing techniques essential for evaluating parenteral drug formulations. Our in-depth knowledge and skill of intermittent and continuous infusion studies for both rodent and nonrodent species can help support your research. Acute to chronic studies requiring infusions of minutes or hours to continuous (24-hour) infusion using indwelling or peripheral catheters can be performed, as appropriate.

To overcome the ever-increasing challenges posed by pharmaceutical and biopharmaceutical compounds, we are continually expanding our range of capabilities to meet the needs for specialized routes of administration. These procedures have also been established to allow us to support the conduct of ICH-compliant reproductive and juvenile toxicology studies utilizing these techniques.

For more information on our juvenile toxicology capabilities, visit the SourceSM.

  • Intravenous as well as subcutaneous infusion studies using external, or if required, implantable programmable micro-infusion pumps
  • Use of target tissue dosing (including cerebrospinal deliveries into the intrathecal, epidural or cerebral spaces) in routine laboratory species
  • Infusion into tumor-bearing animals for efficacy studies, dosing and sampling via dual vascular catheterization and peritoneal fluid exchanges
  • Cardiovascular monitoring by radiotelemetry
  • Cardiac biomarker profiling
  • Neurological assessments
  • Cerebrospinal fluid (CSF) sampling
  • Vitreous and ocular tissue sampling
  • Terminal whole-body perfusion
  • Specialized histopathology techniques

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