Infusion Toxicology

Charles River has decades of experience in the conduct of safety and efficacy studies utilizing infusion dosing techniques essential for evaluating parenteral drug formulations. Our in-depth knowledge and skill of intermittent and continuous infusion studies for both rodent and nonrodent species can help support your research. Acute to chronic studies requiring infusions of minutes or hours to continuous (24-hour) infusion using indwelling or peripheral catheters can be performed, as appropriate.

To overcome the ever-increasing challenges posed by pharmaceutical and biopharmaceutical compounds, we are continually expanding our range of infusion toxicology services to meet the needs of this specialized route of administration. Procedures have been established to allow us to support the conduct of ICH-compliant reproductive and juvenile toxicology studies utilizing infusion techniques. For more information on our juvenile toxicology capabilities, visit the Source℠.

  • Intravenous as well as subcutaneous infusion studies using external or, if required, implantable programmable micro-infusion pumps
  • Use of target tissue dosing (including cerebrospinal deliveries into the intrathecal, epidural or cerebral spaces) in routine laboratory species
  • Infusion into tumor-bearing animals for efficacy studies, dosing and sampling via dual vascular catheterization and peritoneal fluid exchanges
  • Cardiovascular monitoring by radiotelemetry
  • Cardiac biomarker profiling
  • Neurological assessments
  • Cerebrospinal fluid (CSF) sampling
  • Vitreous and ocular tissue sampling
  • Terminal whole-body perfusion
  • Specialized histopathology techniques

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Lab Support

Miss Us at SOT 2017?

Access the recordings of our four exhibitor sessions and downloadable versions of our poster presentations from SOT 2017.

Designing an Infusion Toxicology Program

This webinar provides an overview of the preclinical processes required to support the development of an infusion drug and the issues that may arise and jeopardize timely submission. (Available in the Source℠)

Scientific Poster

This poster shows that concomitant surgical implantation of a femoral intravenous catheter and an intrathecal catheter in juvenile large animals can be successfully achieved and well tolerated.



Enhanced immune evaluations are often needed for small molecule drugs known to have receptors in immune organs.