Infusion Toxicology

Development programs may require the use of increasingly complex infusion procedures to mimic the clinical route or to allow sufficient exposure for safety assessment purposes. With sophisticated capabilities and global facilities, our experts have over 300 years of cumulative experience performing infusion studies with integrated endpoints, resulting in comprehensive and robust solutions for our clients’ infusion needs.

We continue to expand our capabilities for specialized routes of administration to best support the conduct of toxicology and safety pharmacology studies that adhere to global regulatory requirements including ICH-compliant reproductive and juvenile toxicology studies that often require these specialized techniques. For more information on our juvenile toxicology capabilities, visit the Source℠.

Do you require infusion modes of delivery? »

  • Intravenous as well as subcutaneous infusion studies using external or, if required, implantable programmable micro-infusion pumps
  • Use of target tissue dosing (including cerebrospinal deliveries into the intrathecal, epidural or cerebral spaces) in routine laboratory species
  • Infusion into tumor-bearing animals for efficacy studies, dosing and sampling via dual vascular catheterization and peritoneal fluid exchanges
  • Cardiovascular monitoring by radiotelemetry
  • Cardiac biomarker profiling
  • Neurological assessments
  • Reproductive assessments
  • Cerebrospinal fluid (CSF) sampling
  • Vitreous and ocular tissue sampling
  • Terminal whole-body perfusion
  • Specialized histopathology techniques

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Lab Support

Miss Us at SOT 2017?

Access the recordings of our four exhibitor sessions and downloadable versions of our poster presentations from SOT 2017.

Designing an Infusion Toxicology Program

This webinar provides an overview of the preclinical processes required to support the development of an infusion drug and the issues that may arise and jeopardize timely submission. (Available in the Source℠)

Scientific Poster

For some pharmaceuticals and biopharmaceuticals, rodent juvenile toxicology studies via the intravenous (IV) route may be required. Access the Source(SM) to learn more about the different methods that can be conducted for these studies.



Enhanced immune evaluations are often needed for small molecule drugs known to have receptors in immune organs.