Neurotoxicology

The neurotoxicology program  at Charles River encompasses a broad range of products, including pharmaceuticals, biopharmaceuticals, chemicals and biomaterials, in both rodent and nonrodent species. The breadth of experience gained from being in the industry for over two decades has provided us with a valuable historical control database for tests in developmental neurotoxicology. We have a knowledgeable staff of scientists and technical personnel who routinely perform neurotoxicity screening tests for possible on- or off-target effects, specialized target tissue delivery, expanded investigative studies and developmental neurotoxicity. 

  • Acute neurotoxicity
  • Subchronic neurotoxicity
  • Developmental neurotoxicity
  • Behavioral developmental toxicity
  • Safety pharmacology
  • NMDA receptor antagonist
     
  • Standard dose routes
  • Routine and specialized routes of parenteral injection or infusion and target-tissue administration
    • Intravenous
    • Subcutaneous
    • Epidural
    • Intrathecal
    • Intracerebroventricular
    • Intracerebral
    • Intracisternal

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