The neurotoxicology program at Charles River encompasses a broad range of products, including pharmaceuticals, biopharmaceuticals, chemicals and agrochemicals, in both rodent and nonrodent species. With over two decades of experience, we have a valuable historical control database for tests in developmental neurotoxicology. We also have a knowledgeable staff of scientists and technical personnel who routinely perform neurotoxicity screening tests for possible on- or off-target effects, specialized target tissue delivery, expanded investigative studies and developmental neurotoxicity.
Neurobehavior, including assays of locomotor activity, rotarod forced activity, water maze learning and memory testing, auditory startle habituation and functional observational batteries
Neurochemistry, including cholinesterase assays in red blood cell, plasma and brain samples, as well as quantification of endogenous levels of neurotransmitters
Neuropathology, including in situ perfusion, morphometry, stereology and qualitative neuropathological evaluations
Drug abuse/dependence liability testing (non-GLP)