Neurotoxicology

The neurotoxicology program at Charles River encompasses a broad range of products, including pharmaceuticals, biopharmaceuticals, chemicals and agrochemicals, in both rodent and nonrodent species. With over two decades of experience, we have a valuable historical control database for tests in developmental neurotoxicology. We also have a knowledgeable staff of scientists and technical personnel who routinely perform neurotoxicity screening tests for possible on- or off-target effects, specialized target tissue delivery, expanded investigative studies and developmental neurotoxicity.

Capabilities include:

  • Neurobehavior, including assays of locomotor activity, rotarod forced activity, water maze learning and memory testing, auditory startle habituation and functional observational batteries
  • Neurochemistry, including cholinesterase assays in red blood cell, plasma and brain samples, as well as quantification of endogenous levels of neurotransmitters
  • Neuropathology, including in situ perfusion, morphometry, stereology and qualitative neuropathological evaluations
  • Drug abuse/dependence liability testing (non-GLP)
  • Acute neurotoxicity
  • Subchronic neurotoxicity
  • Developmental neurotoxicity
  • Behavioral developmental toxicity
  • Safety pharmacology
  • NMDA receptor antagonist
  • Standard dose routes
  • Routine and specialized routes of parenteral injection or infusion and target-tissue administration
    • Intravenous
    • Subcutaneous
    • Epidural
    • Intrathecal
    • Intracerebroventricular
    • Intracerebral
    • Intracisternal

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