Ocular Toxicology

Charles River performs safety and efficacy assessments on compounds or implantable devices intended for ocular treatment. Ocular effects of compounds administered by other routes, such as oral, can also be characterized. These studies can be conducted under GLP conditions either as stand-alone studies or as part of general and specialty toxicology programs. Non-GLP pilot or proof-of-concept studies are also available for your early research.

Visit the Source℠ for additional information on our ocular research capabilities.

  • Age-related macular degeneration (wet/dry)
  • Macular edema
  • Diabetic retinopathy
  • Congenital/genetic retinal degeneration
  • Glaucoma
  • Neuroprotection
  • Inflammation
  • Dry eye
  • Retinal detachment
  • Retinal hemorrhage
  • Surgical aid
  • Specular microscopy for noninvasive, in vivo evaluation of the corneal endothelium
  • Electroretinography
  • Spectral domain optical coherence tomography (SD-OCT)
  • Tonometry (IOP) evaluations
  • Pachymetry (corneal thickness)
  • Digital fundus photography/video
  • Confocal scanning laser ophthalmoscope (multiple image modes - infrared and tomography for 3D images)
  • Fundus autofluorescence
  • Fluorescein angiography (FA) and Indocyanine green angiography (ICG)
  • Vitrectomy
  • Quantitative autoradiography
  • Ocular and systemic tissue distribution
  • Enhanced microscopic evaluation
  • Ocular surgery/implant

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Specialized Ocular Pathology

Under the guidance of pathologists specialized in ocular toxicology work, Charles River provides one of the most experienced ocular pathology teams in the contract research industry. Visit the Source℠ for more information.

Keeping an Eye on Ocular Toxicity

This webinar will discuss the incorporation of ocular endpoints usually reserved for ocular-specific studies into GLP general toxicology studies, either at the request of the regulators or due to effects observed in previous studies or known compound class effects.

Retinal Degeneration and Neuroprotection Model

We now offer a blue light exposure model that induces retinal damage and cell death, which can be used as a screen for investigating potential neuroprotective properties of new chemical entities prior to subsequent nonclinical testing.