Phototoxicology

Charles River scientists pioneered the quantitative study of cutaneous photobiology by designing instruments, techniques and protocols now accepted as industry standards, and then extended these technologies to ocular phototoxicity and other specialty areas. We utilize a solid knowledge of different light sources and use industry standard calibrated and validated spectroradiometric and radiometric monitoring instrumentation.

All this fits with extensive experience of animal and in vitro models to provide study designs that meet both standard and specialized requirements, with the assurance that the light quality and quantity is accurate and repeatable, regardless of the source. 

  • Cutaneous phototoxicology
  • Ocular phototoxicology
  • Acute and chronic exposure methodologies
  • Specialty phototoxicology, including photodynamic therapies
  • In vitro phototoxicology
  • Regulatory experience in the phototoxicology field
  • 6500W xenon arc solar simulator with multiple filtration configurations to meet evolving regulatory needs
  • Fluorescent sources, both ultraviolet and visible
  • Evaluation of both phototoxicity and photoprotection test materials
  • Custom design of exposure and light source systems
  • Specific wavelength exposure protection
  • Exact spectral distribution and exposure dose characterization
  • FDA-compliant validated radiometry and spectroradiometry systems
  • Expertise in ocular phototoxicity in rats and rabbits

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