Funded by the NIH as part of the second phase of the Knockout Mouse Project (KOMP2), the DTCC Consortium is creating a repository of knockout mouse lines and phenotype data as part of an international effort to help researchers develop better models of human disease. University of California, Davis (UC Davis), Toronto Centre for Phenogenomics (TCP), Children’s Hospital Oakland Research Institute (CHORI) and Charles River have come together to form the DTCC Consortium for this 5-year research effort. In addition to the DTCC Consortium, the other KOMP2 participants include The Jackson Laboratory as well as the collaboration of Baylor College of Medicine, the Wellcome Trust Sanger Institute and the Medical Research Council (MRC) Harwell.

Listen to this podcast to learn more about the DTCC and its mission. 

 

The DTCC Consortium offers access to the phenotyping platform used on the mutant mouse models as well as additional specialized phenotyping platforms at our facilities, including:

  • Comprehensive gross necropsy and histopathology 

  • Additional behavioral testing, including learning and memory 

  • Multimodality imaging of adult animals 

  • Metabolic phenotyping

The DTCC can also assist in accessing models developed at the other International Mouse Phenotyping Consortium (IMPC) centers whose primary phenotyping results reveal phenotypes of interest to your scientific development team. In addition, our frozen and fixed tissue bank is available for collaborative and follow-up evaluation. To discuss your research or a potential collaboration with the DTCC Consortium, please contact us at dtcc@komp.org.

 


To maximize the value of the DTCC Consortium effort, we want to know about the therapeutic areas, disease models and phenotyping information of interest to you. Further, we welcome suggestions from the scientific community to help us grow. This includes input regarding our phenotyping program, nominations of genes for model development and suggestions on focal areas in specific research. Contact us at dtcc@komp.org.