The repTOP™ PPRE-Luc Mouse: A Tool for the Measurement of Peroxisome Proliferator Activated Receptor (PPAR) Activity Systematically

The repTOP™ PPRE-Luc model was created to study the transcriptional activity of PPARs in vivo. The mouse carries a luciferase reporter gene under the control of a pan-PPAR receptor responsive element and was generated with a technology ensuring its ubiquitous expression and regulation.  This transgenic model is suitable for the study of PPAR’s physiopathology action and for the profiling of drugs active through this receptor family. 

Presenter: Pam Riley, Scientific Development Director