Avoid Program Set-Backs: Deciphering Positive Responses


Positive findings from standard genetic toxicology screening and regulatory assays occur frequently enough. But how do you determine which positive responses are truly damaging to your program?

Along with identifying influential “positives”, our scientists discuss assays that are used to characterize positive responses by determining mechanism of action and relevance to human health, including:

  • Immunoflourescent antikinetochore (CREST) & flouresence In Situ Hybridization (FISH) Assays
  • In vivo mammalian alkaline comet assay (OECD 489)
  • Pig-a assay
  • ToxTracker assay
  • MultiFlow™

Presenters

  • Ilona Verbaan, PhD, MSc, BS, Section Head Discovery, Genetic and In Vitro Toxicology, Charles River
  • Renato Cardoso, PhD, DABT, Scientific Director, Genetic Toxicology, Charles River

Panelist

  • Leon Stankowski, PhD, Scientific Director, Genetic and In Vitro Toxicology, Charles River

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