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Preconditioning Services: Aging Services for the Development of Disease Conditions
In some models, the disease condition develops only as the animal ages. Such models need to be held and aged prior to being placed on study. Charles River can hold and care for these the animals and deliver them to you at the point in time that you determine.
The SHHF rat is a model of congestive heart failure in which all genotypes and sexes are hypertensive and develop heart failure. The obese male will develop heart failure by 13 months of age, the lean male and obese female by 18 months of age, and the lean female after 23 months of age.
The JCR rat is a model of vascular and myocardial disease. Myocardial and atherosclerotic lesions occur in this model after 9 months of age. Although early atherosclerotic changes are evident in obese males at 12 weeks and increase in severity with age, it is not until 9 months of age when essentially all of the obese males have advanced intimal lesions of the aortic arch.
In addition to aging models for the development of disease conditions, we offer “Off-the-Shelf” aged C57BL/6NCrl mice (male only) and Crl:CD(SD) rats (both sexes) for use in various studies. These animals are set aside at six weeks of age and held for up to 16 months in static micro-isolator cages in an AAALAC-accredited barrier room production facility. Please contact us at 1-800-522-7287 to confirm current availability and to place orders.
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