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Preconditioning Services: Feeding Studies
With the increased demand to find new drugs for use in the study of obesity, diabetes, nutrition, hypertension, and stroke, many researchers now need animals that have been pre-fed enriched diets. With preconditioning services, you can purchase your animals ready to use and save valuable laboratory space for your actual study.
Custom Diet-Induced Obesity Program
Charles River offers both rat and mouse models for obesity studies. These models can be fed a special diet as directed by you to induce obesity before being shipped. Typical models used to study obesity include:
- C57BL/6 Mice
- CD Rats
- DIO Rats
In order to reduce your study start time, we currently offer "Ready-to-Go" DIO male C57BL/6NCrl mice. Figure A shows the increase in body weight of male C57BL/6NCrl mice maintained on a DIO regimen (Research Diets D12492) compared to a regular chow diet (p<0.05 at week 14-24). Please contact Customer Service at 1-800-522-7287 to confirm current availability and to place orders.
Specialty Models Program
Some models need to be fed a special diet to accelerate the development of a characteristic trait or condition, such as hypertension or diabetes. We can now precondition these models and feed them the special diets necessary for maximum expression of the phenotype of interest. These models include:
- Dahl/Salt Sensitive Rat - develops hypertension when fed a specific salt diet
- SHR/SP Stroke Prone Rat – develops hypertensive cerebrovascular disease (Note: Although the disease will develop spontaneously in the SHR/SP rat, a much more consistent and higher incidence of stroke will develop when this model is fed a Stroke-Prone diet.)
- Female ZDF Rat - becomes diabetic in approximately one month when fed a diabetogenic diet
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