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June 18, 2008
Charles River Introduces SCID Hairless Outbred (SHO) Mouse
Many xenograft tumors grow better in SCID mice than in nude mice. However, the use of SCID mice in oncology research is significantly hindered by their hair coat, which makes tumor measurement difficult. As a result, researchers often use nude mice (T cell-deficient only) to avoid the complication of shaving the SCID mouse. SCID mice have severe combined immune deficiency, affecting both B and T lymphocytes while maintaining normal NK cells, macrophages, and granulocytes.
In 2007, Charles River began a breeding project to develop a hairless SCID mouse from Crl:HA-Prkdcscid and Crl:SKH1-Hrhrstocks. The resulting mouse is the double-homozygous SCID hairless outbred (SHO). While the model is still being characterized, basic analysis suggests that tumors in the SHO mouse will grow similarly to tumors in other SCID mice, yet seeing and measuring those tumors will be as easy as with nude mice.
We are excited about this model's potential and would like to keep you informed of its progress. We are expanding the colony and completing baseline studies. We have recently completed a xenograft study and compiled the results into a white sheet entitled In vivo Tumor Growth of the Human Prostate Cell Line PC-3 in the SHO Mouse. Additionally, in the coming months, the following information will be available:
- Clinical chemistry data
- Immunological characterization
- Additional xenograft studies
If you would like to receive any of the information above, please complete our brief on-line survey and we will be happy to send you the updates as they become available.
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