Charles River offers an integrated approach to ophthalmology research. Compounds or implantable devices intended for ocular treatment can be assessed for efficacy, safety and toxicity in multiple species. Ocular effects of compounds administered by other routes, such as oral, can also be characterized. These studies can be conducted under GLP conditions either as stand-alone studies or as part of general and specialty toxicology programs. Non-GLP pilot or proof-of-concept studies are also available for your early research needs. Basic Research New Zealand White (NZW) Rabbit Zucker Diabetic Fatty (ZDF) Rat Spontaneously Hypertensive (SHR) Rat Operations & Staffing Support Drug Discovery In Vivo Pharmacology Studies Discovery Pathology Studies Biomarker & Analytical Services Safety Assessment Ocular Distribution Studies General Toxicology Studies Ocular Toxicology Studies Genetic Toxicology Studies Immunohistochemistry & Tissue Cross-Reactivity In Vitro Toxicology Models Ocular Pathology Services Clinical Support Clinical Bioanalysis Clinical Pharmacokinetics Clinical Immunology and Biomarker Services Pathology for Clinical Trials Manufacturing Support GMP-Compliant Biopharmaceutical Manufacturing Endotoxin Detection and Microbial Identification