2019 SOT Annual Meeting & ToxExpo Scientific Resources

The 58th Annual Meeting of the Society of Toxicology
Baltimore, MD | March 10-14

Profile of a female scientist looking through a microscope in front of a computer screen.

Charles River was proud to support the 2019 SOT Annual Meeting and ToxExpo. Below, you can download any of our poster presentations and explore other resources covering a full range of general and specialty toxicology topics. 

Would you like to connect with one of our SOT presenters? Contact us today.

New trends and guidance documents are being released regularly. Our experts stay ahead of these changes and are sharing their insights in a series of interview videos focusing on SEND, rare diseases, imaging, just to name a few.

SEND: What to Expect

Audrey Walker, Director of SEND, and Christy Kubin, Associate Director of SEND, discuss the new guidance’s and what to expect with SEND requirements.

 

Flow Cytometry Trends

Marie-Soleil Piche, Scientific Director for Immunology at Charles River, discusses the latest in flow cytometry trends.

Scientists from different disciplines presented at the SOT Annual Meeting & ToxExpo. Click the links below to watch their poster presentation video.

Successful Application of Automated Liquid Handlers in Bioanalysis to Meet the Increasing Demand of Faster Timelines in Support of Toxicology Studies*
Kelly Colletti, Associate Director, Research
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Identifying the Mode of Action of Potential Genotoxicants Using Nuclear Biomarkers in TK6 Cells
Daniel Roberts, Principal Research Scientist, Genetic In Vitro Toxicology
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Magnetic Resonance Imaging (MRI) and Histopathology Characterization of Osteoarthritis (OA)-associated Lesions in a Large Animal Surgical Model*
Martin Guillot, Principal Research Scientist, Musculoskeletal Research
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Assessment of Alveolar Toxicity and Fibrotic Potential In Vitro using the MatTek EpiAlveolar Model
Clive Roper, Head of In Vitro Sciences
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*Items marked with an asterisk can be viewed in our secure portal, The Source℠, and some titles have been changed to protect sensitive content.

Our experts presented on multiple topics during SOT and you can download any of our poster presentations.

Monday, March 10

Identifying the Mode of Action of Potential Genotoxicants Using Nuclear Biomarkers in TK6 Cells
Daniel J. Roberts1, Jahna Soomer-James1, Brian Lallier1, Matt Lorenz1, Vincent Kwok1, Steve Bryce2,
and Leon F. Stankowski, Jr.1
1Charles River Laboratories, Skokie, IL 2Litron Laboratories, Rochester, NY

Validation of an in Vitro Test Battery to Evaluate Smokeless Tobacco Products
Sara B. Hurtado, Brian Lallier, Daniel J. Roberts, Regina Puskorius, Vincent Y. Kwok, and Leon F. Stankowski Jr. (sponsored by Christopher S. Farabaugh;)Charles River Laboratories, Skokie, IL

Tuesday, March 11

Magnetic Resonance Imaging (MRI) and Histopathology Characterization of Osteoarthritis (OA)-Associated Lesions in a Large Animal Surgical Model*
Martin Guillot1, A. Bédard1, A. Landry2, F. Emond1, C. Foucault1, L. Tremblay3, A. Varela1
1Charles River Laboratories Montreal, Canada; 2Charles River Laboratories Sherbrooke, Canada; 3CIMS-CRCHUS, University of Sherbrooke, Sherbrooke, Canada

Micro-CT and Histopathology Characterization of Atherosclerotic Plaque in Aorta From High Fat Diet-Fed Ovariectomized Apolipoprotein E Knockout Mice
Martin Guillot1, G. Boyd1, J-G. Bienvenu1, M. Felx1, C. Glaus2, J. Turk2, V. Stadelmann3, A. Varela1
1Charles River Laboratories Montreal, Canada; 2Amgen, Thousand Oaks, CA; 3CIMS-CRCHUS, University of Sherbrooke, Sherbrooke, Canada

Wednesday, March 12

Capture Compound® Mass Spectrometry: Elucidating Off-Target Binding to DeconvoluteDrug Toxicity
S. Almond, E. Bush, A. Cridland, S. Dowler, G. Hardman, D. Kenny, I. Linney, N. Macabuag, D. Mitchell, P. Mitchell; Charles River Laboratories, Saffron Walden, UK

Thursday, March 13

Ambulatory Intravenous Infusion in Large Animals*
Julie Douville, Stefania Cinquino, Nathalie Lecompte, Sonia Talbot; Charles River Laboratories, Montreal

An Evaluation of the Guinea Pig for use on Cardiovascular Safety Studies
Brian Roche, John Ross, Brent Walling, Michelle Waines, Kristen Ford, Bethani Woods, and Samuel Foust; Pharmacology and Discovery Services, Charles River Laboratories, Ashland, OH

Application of a 3D Model of Human Liver Cells Co-cultured with Human Lymphoblast in the Evaluation of Comet and Micronucleus
Renato Cardoso, Thalita BoldrinZanoni, Annie Hamel; Charles River Laboratories, Montreal, Canada

Assessment of Alveolar Toxicity and Fibrotic Potential In Vitro using the MatTekEpiAlveolar™ Model
CS Roper, JE Baily, HJ Simpson and JL Vinall; Charles River Laboratories, Edinburgh, UK

Comet Assay in 3D HepaRGTMSpheroid Model: A Promising Tool to Evaluate DNA Strand Breaks Using Human Liver Cells
Renato Cardoso, Thalita Boldrin Zanoni, Annie Hamel; Charles River Laboratories, Montreal, Canada

Comparison of TK6 Micronucleus Data Generated by Flow Cytometry and Microscopy
Vincent Kwok, Krista Anderson, Andrew Boggs, Christopher S. Farabaugh, Pamela Heard, Sara Hurtado, Brian Lallier, Matt Lorenz, Sarah Marsh, Erica Pinkus, Amy Reeder, Jahna Soomer-James, Leon F. Stankowski Jr., Sarah Tincher, Caitlyn Tydrick, Melissa Wells, and Daniel J. Roberts; Charles River Laboratories, Skokie, IL

Contractility: Can a Rodent Model be Utilized as a Suitable Alternative to Large Animal Telemetry to Assess Potential Inotropic Effects of Novel Compounds?*
Kevin Norton, Jessica Sessenwein, Nataliya Sadekova, Ghislaine Boudreau and Mark Vezina; Charles River Laboratories Montreal

Development of a Large Animal Vaccination Model to Assess CD8 T Cell Specific Responses*
Richard Graveline1, Morad Haida1, Carolyne Dumont1, Dominic Poulin1, Rana Samadfam1, Franziska Regenass2, Sven Kronenberg2 and Marie-Soleil Piche1
1Charles River Laboratories, Senneville, Quebec, Canada, 2F. Hoffmann-La Roche Ltd.,pREDRoche Innovation Center Basel (Pharmaceutical Sciences), Switzerland

Development of LC-MS/MS Assays to Measure Thyroid Hormones in Rat Serum
Elizabeth A. Groeber, Hua Wang, Seth R. Bell, Junhong Guo, Jeroen Kooistra, Pragati S. Coder and Liam B. Moran; Charles River Laboratories, Ashland, OH

Distinct Carbon Sources Determine the Response of Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Hypoxia
Andrew Bruening-Wright and Carlos Obejero-Paz; Charles River Laboratories

Immunotoxicology Evaluation in the Juvenile Göttingen Minipig
Linda Allais, Fabienne Condevaux, Alicia Perbet, Alan Hoberman; Charles River, Lyon, France

Intrathecal Administration by Direct Lumbar Injection in the Rat and Large Animal*
C. Voyer, J. Douville, L. Chouinard, F. Emond, C. Foucault, M. Halle; Charles River Laboratories, Senneville, Quebec, Canada

Re-evaluation of Discordant Results in Related OECD TG471 Tester Strains
Christopher S. Farabaugh, Brian Lallier, Caitlin Tydrick, Richard Baba, Sarah Tincher, Jesus Callupe, Vincent Y. Kwok, and Leon F. Stankowski, Jr.; Charles River Laboratories, Skokie, IL

Reliable Method for Intravenous Dosing in Guinea Pigs
Jenkins, C.1, Shaffer, J.1, Kearney, K.1, Lewis, E.2, Thompson, K.2, Tan, A.3, Bee, W.4
1Charles River Laboratories, Ashland, OH 2Charles River Laboratories, Horsham, PA 3Aggamin, New York, NY; and 4QPS LLC, Newark, DE.

Successful Application of Automated Liquid Handlers in Bioanalysis to Meet the Increasing Demand of Faster Timelines in Support of Toxicology Studies*
Davidson, T.; Soukup, E.; Colletti KS.; and Patel, V.; Charles River Laboratories

What to do with Unwanted Inflammation; Dealing with the Impact of Delayed Downstream Immunomodulation Induced by Test Article Administration
Gina N. Wilson, Brian M. Roche; Charles River Laboratories, Ashland, OH

*Items marked with an asterisk can be viewed in our secure portal, The Source℠, and some titles have been changed to protect sensitive content.