Exhibitor Hosted Sessions

Register or log into the SOT 2021 Virtual Meeting Platform to sign-up for these sessions and to join the conversation.

March 16, 2021 | 9:00 AM – 10:00 AM

Pathology V 2.0: Digital is Here

Daniel G. Rudmann, Scientific Director, Digital Pathology

Study and peer review pathologist assessments are critical for study reporting and development decision making. The COVID pandemic has complicated the peer review workflow and accelerated the adoption of digital alternatives. We’ll review the use and qualification of digitized whole slide images as an alternate to traditional glass slide review.

March 17, 2021 | 9:00 AM – 10:00 AM

Targeted Delivery Considerations for Administrations of Gene Therapies to the Central Nervous System

Barak Gunter, PhD, Sr. Research Scientist
Shawna M. Jackman, PhD, DABT; Sr. Principal Research Scientist

Gene therapies involving targeted delivery routes of administration require many considerations for successful preclinical development. This session will review the complexities of targeted administration including MRI-guided delivery. The session will also review the regulatory perspectives supporting study designs and the specialized study logistics, techniques and endpoints unique to these programs.

March 22, 2021 | 9:00 AM – 10:00 AM

Underexposed Topics in Endocrine Disruption Testing: Thyroid Modalities, Nontarget In Vitro Assays and Mode of Action Analysis

Mira Wenker, PhD, CRL-HER, CRL ED Expert team
Dan Pickford, PhD, Principal Technical Expert, Environmental Safety, Syngenta
Pramila Singh, PhD, Scientific Director and Senior Director of Toxicology

This session will focus on aspects of endocrine disruption testing that are new or have not received much attention. Developments in in vitro assays for thyroid testing and non-mammalian testing will be highlighted and examined. Use of mode of action studies will illustrate how to determine relevance to human health.

March 23, 2021 | 9:00 AM – 10:00 AM

Strategies to Evaluate the Risk of UGT-Mediated Drug-Drug Interactions

Jelle Reinen, PhD, Group Leader, In Vitro Drug Metabolism and Pharmacokinetics

This session will discuss assays and strategies to employ UDP-glucuronosyltransferase (UGT) assays for characterization, induction, and inhibition studies. We will present our improved strategy comparing the potential induction of cytochrome P450 (CYP) and UGT between different species using enzyme activity and mRNA analysis as endpoints.