2021 SOT Virtual Event Poster Presentations

Wednesday, March 17 | 11:15 AM – 1:00 PM

P105: Development of a Strategy to Determine the In Vitro Induction of T4-Glucuronidation in Rat and Human
Jelle Reinen, Maarten Smit, Betina Elemark, Mira Wenker

Thursday, March 18 | 11:15 AM – 1:00 PM

P145: Evaluation of Drug Displacement from Melanin as a Screening Method for Retinal Toxicity
Adrian Sheldon, Patty Walton, Sarah Meloche, Karen Stams, CO-AUTHORED WITH BIOGEN
P147: A 1-Month Toxicology and Biodistribution NHP Pilot Study Evaluating a Single Subretinal Bilateral Administration of SPVN06 - A Novel AAV-based Gene Therapy for Treatment of Rod-Cone Dystrophies Agnostic of the Causative Mutation
Thomas Vihtelic, Ryan Boyd, Lauren Knupp, co-authored with Institut de la Vision, University of Pittsburgh

Tuesday, March 23 | 11:15 AM – 1:00 PM

P129: Implementation of an In Vitro FTC-238-hr TPO-based Tyrosine Iodination Method to Evaluate Chemicals for Thyroperoxidase (TPO)-Inhibiting Properties
Jeroen Rijk, Ester de Laat, Gijs van Slobbe, Jan Toersche, Mira Wenker CO-AUTHORED WITH EU Commission Joint Research Centre, and US FDA/NCTR
P206: A New 90-day Drinking Water Study of Sodium Cyanide in Rats to Further Evaluate NTP Findings and Inform Risk Assessment
Melinda Tyner, Pragati Coder
P275: A GLP Validation of the 3D Skin Comet Assay Using Phenion Full-Thickness Skin Models: An Alternative to Animal Testing
Thalita Zanoni, Annie Hamel
P276: Application of Liver-on-Chip Integrated with Human Lymphobastoid Cells (TK6) to Genotoxicity Testing: Go with the Flow and Reduce Animal Testing
Annie Hamel, Deborah Lenart, Ammer Khawam, Karen Di Perna, Thalita Zanoni
P294: Next Generation Risk Assessment Approach for Inhalation: Polymer Case Studies
J. Wallace, co-authored with Unilever and IIVS and Epithelix

Wednesday, March 24 | 11:15 AM – 1:00 PM

P156: Optimization of Extraction Method B Using Common Organic Solvents for Dosing in Genotoxicity In Vitro Assays
Farida Merah
P174: Comparison of Immunoconditioning Regimens for Cell Therapy Toxicology Studies Using the NCG or NSG Mouse Models
Robert Tavcar, Cristina Ballersteros, Christian Li., Selly Hung, Karen Wong, Simon Authier
P167: Retrospective Analysis on the Tolerability of Commonly Used Vehicles in Nonclinical Studies
Coralie Perret, Claire Tardiveau, Nathalie Truchot-Limonne, Laure Penard, and Stephane Baudet

Thursday, March 25 | 11:15 AM – 1:00 PM

P102: Development of Rat Models of Acute Respiratory Distress Syndrome (ARDS) for Efficacy and Safety Assessment
Mary McElroy, James Punton, Angela Marsden, Pan Fillis, Kristen Maclellan, James Baily, Aileen Milne
P109: Enhancing the Environment for Rodents in Toxicology Studies
Emmanuel Boulay, Robert Tavcar, Christian Li, Elizabeth Lambert, Julie Roy, Marika Arsenault, Simon Authier
P171: Seizure Assessments in Preclinical Species: Review of Data Analysis Strategies
Simon Authier, Michael Accardi, Robert Tavcar, Phoebe Zhong, LoΪs Miraucourt, Jerneja Stare, Christian Li, and Erik Larson
P165: Differences in Spontaneous Neoplastic Incidence in Crl:CD(SD) Rats and Crl:WI(Han) Rats
Mark Morse, Christopher Papagiannis, Don Stump
P166: Reproducibility of Survival and Spontaneous and NMU-Induced Neoplastic Incidence in CByB6F1-Tg(HRAS)2Jic (Tg.rasH2) Mice over the Last Decade
John Ciallella, Kimberly Bonnette, Mark Morse

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