Pain stimuli activate nerve fibers called nociceptors that relay signals via multiple pathways to the brain. Ion channels underlie the electrical signaling throughout the body so modulators of ion channels have the potential to be effective pain therapies.
This webinar highlights key voltage and ligand-gated ion channels involved in the pain pathways and the process of identifying novel therapeutic candidates using automated electrophysiology platforms that could potentially treat nociceptive pain.
- Gary Clark, PhD, Research Fellow, Integrated Biology, Charles River
- Ion Channel Selectivity Profiling (Datasheet)
- Validated Acute and Inflammatory In Vivo Pain Models for Drug Discovery (Webinar Replay)
- Development and validation of ligand-gated ion channel assays using the Qube 384 automated electrophysiology platform (Poster)
- Multi-parameter ion channel screening: mechanism-of-action data directly from HTS (Poster)