LER: A Biopharmaceutical Operational Reality Perspective

    
        


The true impact of LER has yet to be elucidated. As such, the LER phenomenon continues to be investigated across many industries, including biopharmaceutical operations. We focus here on LER from an operational reality perspective: the growth of organisms in LER matrices and consequently the endotoxin they produce.

This webinar provides a comprehensive review of the following topics:

  • Differentiating physical and chemical properties of purified lipopolysaccharides and native endotoxins (NOE) under LER and non-LER conditions
  • Data from experiments simulating the microbiological outgrowth in LER matrices
  • Results from comparative in vitro and in vivo rabbit pyrogen experiments with native bacterial endotoxins

Presenter

  • John Dubczak, General Manager, Microbial Solutions, Charles River