Annie Hamel is the Associate Director of Genetic Toxicology, where she oversees a department conducting GLP projects that will be submitted to regulatory agencies. She has directed over 350 in vitro and in vivo safety assessment studies at the Montreal site and has experience working with comet assays and 3D cultures with metabolic competency. Before taking on her new role, Annie was responsible for the development and implementation of new assays in addition to software validation for automated implementation at the Montreal site. Annie has been with Charles River for over 18 years, including more than 10 years' experience working with genetic toxicity testing.
Annie has a master’s degree in biology, specializing in toxicology and human and animal physiology, from the Université du Québec à Montréal (UQAM). She is a committee member for EMGS and has authored/co-authored many scientific posters and publications.
- Anette Thiel, Annie Hamel, Katrien Schaefer, Renato Cardoso, Paul Beilstein. Slight hypercalcemia is not associated with positive responses in the Comet-Assay in male rat liver. Mutat Res Gen Tox En 820 (2017) 26-30.
- Formulation of Test Article. Annie Hamel and Ray Proudlock (Chapter 3), in Genetic Toxicology Testing: A Laboratory Manual, edited by Ray Proudlock, Elsevier Inc. (2016).
- The Bacterial Reverse Mutation Test. Annie Hamel, Marise Roy and Ray Proudlock (Chapter 4), in Genetic Toxicology Testing: A Laboratory Manual, edited by Ray Proudlock, Elsevier Inc. (2016).
- Lafond J, Hamel A, Takser L, Vaillancourt C, Mergler D. Low environmental contamination by lead in pregnant women: effect on calcium transfer in human placental syncytiotrophoblasts. J Toxicol Environ Health A. 2004 Jul 23;67(14):1069-79.
- Hamel A, Mergler D, Takser L, Simoneau L, Lafond J. Effects of low concentrations of organochlorine compounds in women on calcium transfer in human placental syncytiotrophoblast. Toxicol Sci. 2003 Nov;76(1):182-9. Epub 2003 Sep 11.
- Moreau R, Hamel A, Daoud G, Simoneau L, Lafond J. Expression of calcium channels along the differentiation of cultured trophoblast cells from human term placenta. Biol Reprod. 2002 Nov;67(5):1473-9.
- May I Leave It for Tomorrow? An Evaluation of the Stability of Micronucleus and Comet Slides
- A Metabolic Competent 3D Liver Sandwich Model with Detoxification Properties Co-Cultured with Human Lymphoblast: Application in the Comet and Micronucleus Assays
- Effect of Slide Positioning in Electrophoresis Chamber over Comet Assay Results
- How Do I Know That I Know How? A Systematic Approach to Implement a New Assay
- Application of a 3D Model of Human Liver Cells Co-Cultured with Human Lymphoblast in the Evaluation of Comet and Micronucleus
- Comet Assay in 3D HepaRGTM Spheroid Model: A promising Tool to Evaluate DNA Strand Breaks Using Human Liver Cells