Neil Williams, Senior Director for Immunology at Charles River Laboratories

Professor Neil Williams

Consultant, Immunology

Professor Neil Williams is a consultant for Immunology at Charles River Laboratories. He was founder and CSO of KWS BioTest Ltd., a recent Charles River acquisition, and also founder of Trident Pharmaceuticals Inc., and inventor of their novel T-regulatory cell modulating therapy. His positions have included Professor of Immunology and Research Director at the University of Bristol, and he has acted as a member of the Discovery Panel at Cancer Research Technology. He brings a huge depth of expertise in immunology and has led a range of programs aimed at the development of novel immune modulating therapies and vaccines for autoimmunity, inflammation and oncology. His expertise in drug discovery enables Charles River to act as true partners in immunology and immuno-oncology for their many clients across Europe and the rest of the world.

Recent Publications:

  1. Vaughan AT, Brackenbury L, Massari P, Davenport V, Gorringe A, Heyderman RS, Williams NA. Neisseria lactamica selectively induces mitogenic proliferation of the naïve B cell pool via cell surfasce Ig. J. Immunol. (2010) 185:3652-2660. 
  2. Glennie, SJ, Williams NA & Heyderman, RS (2010) Trends Microbiol 18:487-493. 
  3. Donaldson DS, Tong KK, Williams NA. Mucosal administration of the B subunit of E. coli heat-labile enterotoxin promotes the development of Foxp3-expressing regulatory T cells. Mucosal Immunol. 2011;4(2):227-38.  
  4. Iwajomo OH, Finn A, Moons P, Nkhata R, Sepako E, Ogunniyi AD, Williams NA, Heyderman RS. Deteriorating pneumococcal-specific B-cell memory in minimally symptomatic African children with HIV infection. J Infect Dis. 2011 Aug 15;204(4):534-43 
  5. Glennie SJ, Sepako E, Mzinza D, Harawa V, Miles DJ, Jambo KC, Gordon SB, Williams NA, Heyderman RS. Impaired CD4 T cell memory response to Streptococcus pneumoniae precedes CD4 T cell depletion in HIV-infected Malawian adults. PLoS One. 2011;6(9):e25610. 
  6. Glennie SJ, Nyirenda M, Williams NA, Heyderman RS. Do multiple concurrent infections in African children cause irreversible immunological damage? Immunology. 2012;135(2):125-32. 
  7. Pido-Lopez J, Kwok WW, Mitchell TJ, Heyderman RS, Williams NA. Acquisition of Pneumococci Specific Effector and Regulatory CD4 T Cells Localising within Human Upper Respiratory-Tract Mucosal Lymphoid Tissue. PLoS Pathog. 201;7(12):e1002396. 
  8. Iwajomo OH, Finn A, Moons P, Nkhata R, Sepako E, Ogunniyi AD, Williams NA, Heyderman RS. Deteriorating pneumococcal-specific B-cell memory in minimally symptomatic African children with HIV infection. J Infect Dis. 2011 Aug 15;204(4):534-43 
  9. Glennie SJ, Banda D, Gould K, Hinds J, Kasmngona A, Everett DD, Williams NA, Heyderman RS. Defective pneumococcal specific Th1 responses in HIV-infected adults precedes a loss of control of pneumococcal colonisation. Clin Infect Dis 2013; 56:291-9
  10. Clarke ET, Williams NA, Dull PM, Findlow J, Borrow R, Finn A, Heyderman RS. Polysaccharide-protein conjugate vaccination induces antibody production but not sustained B cell memory in the human nasopharyngeal mucosa. Muc Immunol 2013; 6:288-96 
  11. Jambo KC, Sepako E, Glennie SJ, Mzinza D, Williams NA, Gordon SB, Heyderman RS. PLoS One 2012; 7(6):e38628
  12. Donaldson, DS, Apostolaki M, Bone HK, Richards CM, Williams NA. The Escherichia coli heat-labile enterotoxin B subunit protects from allergic airway disease development by inducing CD4+ regulatory T cells. Muc Immunol 2013; 6:535-46. 
  13. Glennie SJ, Banda D, Mulwafu W, Nkhata R, Williams NA, Heyderman, RS. Regulation of naturally acquired mucosal immunity to Streptococcus pneumonia in healthy Malawian adults and children. 2013; 7: e51425 
  14. Clarke ET, Williams NA, Findlow J, Borrow R, Heyderman RS, Finn A. Polysaccharide-specific memory B cells generated by conjugate vaccines in humans conform to the CD27+IgG+ isotype-switched memory B Cell phenotype and require contact-dependent signals from bystander T cells activated by bacterial proteins to differentiate into plasma cells. J Immunol. 2013 Dec 15;191(12):6071-83.
  15. Iwajomo OH, Finn A, Ogunniyi AD, Williams NA, Heyderman RS. Impairment of Pneumococcal Antigen Specific Isotype-Switched Igg Memory B-Cell Immunity in HIV Infected Malawian Adults PLoS One. 2013 Nov 4;8(11):e78592. doi: 
  16. Hallissey CM, Heyderman RS, Williams NA. Human Tonsil-derived Dendritic Cells are Poor Inducers of T cell Immunity to Mucosally Encountered Pathogens. J Infect Dis. 2014 Jan 19. 
  17. Xie Q, Brackenbury LS, Hill DJ, Williams NA, Qu X, Virji M. Moraxella catarrhalis adhesin UspA1- derived recombinant fragment rD-7 induces monocyte differentiation to CD14+CD206+ phenotype. PLoS One. 2014 Mar 5;9(3):e90999 
  18. Iwajomo OH, Moons P, Nkhata R, Mzinza D, Ogunniyi AD, Williams NA, Heyderman RS, Finn A. Delayed reconstitution of B cell immunity to pneumococcus in HIV-infected Malawian children on antiretroviral therapy. J Infect. 2014 Nov 1. pii: S0163-4453(14)00326-0 
  19. Andrade GR, New RR, Sant'Anna OA, Williams NA, Alves RC, Pimenta DC, Vigerelli H, Melo BS, Rocha LB, Piazza RM, Mendonça-Previato L, Domingos MO. A universal polysaccharide conjugated vaccine against O111 E. coli. Hum Vaccin Immunother. 2014;10(10):2864-74 
  20. Ondondo B, Faulkner L, Williams NA, Morgan AJ, Morgan DJ. The B subunit of Escherichia coli enterotoxin helps control the in vivo growth of solid tumors expressing the Epstein-Barr virus latent membrane protein 2A. Cancer Med. 2015 Mar;4(3):457-71. doi: 10.1002/cam4.380. 
  21. Bailey JR, Vince, V, Williams NA, Cogan TA. Streptococcus thermophilus NCIMB 41856 ameliorates signs of colitis in an animal model of inflammatory bowel disease. Benef. Microbes 2017 Aug 24;8(4):605-614. doi: 10.3920/BM2016.0110.