Our portfolio of unique capabilities and state-of-the-art instrumentation can support and advance your neuroscience and rare disease research. View our drug discovery videos, which cover topics such as brain slice electrophysiology, fine motor kinematics, MRI, PET imaging, and touchscreen testing, to learn more about some of our capabilities.
Electrophysiology is used to detect both pathological changes and pharmacological responses via the measurement of spontaneous and evoked electrical signals. Charles River offers a comprehensive portfolio of electrophysiology assays including brain slice assays that use multi-electrode arrays to measure signals from multiple areas of the brain. This video combines interview and experimental lab footage to highlight the sample preparation and data analysis and capture and highlights the utility of brain slice electrophysiology assays in a neurological drug discovery program. Watch now
Impairment of fine motor skills is used as an early diagnosis marker in muscular degenerative and neurodegenerative diseases. At Charles River, we analyze changes in gait and balance in mouse models of movement disorders using a highly translational method called fine motor kinematic analysis. The kinematic method is capable of detecting small changes in movement that may be undetected by more conventional tests such as the cat walk and rotarod. This video combines interview and experimental lab footage to highlight the kinematic gait analysis method and Charles River’s proprietary data analysis that provides a multi-parametric quantitative measure of gait and balance changes. Watch now
Microdialysis is a sampling technique that can be used in multiple tissues and tumors to sample analytes that are then measured using existing bioanalytical methods. Analytes include neurotransmitters, brain metabolites as well as therapeutic compound concentrations. At Charles River, the microdialysis method has been optimized to sample large molecules including peptides, proteins and antibodies (push-pull method) and is also used to recover maximal amounts of free drug concentrations. This video combines interview and experimental lab footage to showcase the utility of microdialysis in drug discovery and how it can be combined with other assays to provide a comprehensive data on a therapeutic modality. Watch now
Magnetic Resonance Imaging (MRI) is a translational method that is used in multiple assays including efficacy testing as a biomarker endpoint, target engagement etc. At Charles River, various MRI modalities are available including structural MRI to study anatomy and white matter mapping, magnetic resonance spectroscopy (MRS) to study metabolic changes, pharmacological MRI to study target engagement and cerebral blood volume and hemodynamic MRI. This video combines interview and experimental lab footage to highlight our MRI expertise and large scale capabilities. Watch now
Positron Emission Tomography (PET) imaging is a translational method to measure metabolic changes and brain function and is increasingly being used as a biomarker endpoint. At Charles River, a combination of access to a cyclotron for radionuclide production, state of the art scanners and expertise in imaging data analysis facilitate comprehensive results This video on PET imaging shows the sample preparation and analysis as well as the data capture, and highlights arterial input function as a key differentiator in dynamic PET imaging. Watch now
Touchscreen testing is a translatable method to measure cognitive decline in mouse models of neurological disease and can be used to perform simple and complex cognitive neuroscience tests. The animal models can be trained to perform increasingly complex tasks to detect small changes in learning and memory that may be undetectable by maze tests. This video combines interview and experimental lab footage to highlight the process of training mice to perform touchscreen tasks in special chambers and data analysis of the test responses. The data is analyzed to identify cognitive changes and flexibility in neurodegeneration and apathetic responses in depression studies. Watch now
Including disease relevant biomarker readouts is essential to generate actionable data. At Charles River’s site in Kuopio, Finland, our comprehensive portfolio of in vivo services are complemented by our state of the art biomarker laboratory where studies using flow cytometry, immunohistochemistry, ELISA and Luminex® assays, and autoradiography are performed to support programs in neuroscience and rare disease drug discovery. In this video, Tuulia Huhtala, PhD, the head of Biomarker lab highlights the biomarker capabilities at the site and discusses how the biomarker services support client studies. Watch now