The human CACNA1C gene encodes the pore-forming subunit of voltage-gated L-type Ca2+ channels. Co-expession with the β2 and α2δ1 auxiliary subunits recapitulates function in heterologous expression (CHO cells). Cav1.2 channels, widely distributed in cardiac and smooth muscle, and in neurons, are therapeutic targets in cardiovascular and neurological diseases.
Human Cav1.2/β2/α2δ1 Calcium Channel EZCells™ DA
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