The human CACNA1C gene encodes the pore-forming subunits of Cav1.2. Inclusion of auxiliary subunits modulate gating and pharmacological properties, while the inwardly rectifying potassium channel allows the membrane potential to be altered with changes in extracellular K+. Cav1.2 channels expressed in heart, smooth muscle, neurons, and endocrine tissue are therapeutic targets in cardiac arrhythmia and hypertension.
Human Cav1.2/β2/α2δ1/Kir2.1 Calcium Channel EZCells™ TT
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