Human Cav1.3/β3/α2δ1/Kir2.1 Calcium Channel Cell Line

The human CACNA1D gene encodes the pore-forming subunit of Cav1.3. CACNB3 and CACNA2D1 encode auxiliary subunits that modulate gating and pharmacological properties. The inducible expression of Kir2.1 provides a mechanism for K+-depolarization of the resting membrane potential to facilitate voltage-dependent activation of the Cav1.3 channels in FLIPR assays.

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