Human Cav2.1/β4/α2δ1 Calcium Channel Cell Line

The human CACNA1A gene encodes the pore-forming subunit of Cav2.1, the voltage-gated P/Q-type calcium channel. CACNB4 and CACNA2D1 encode auxiliary subunits that modulate gating and pharmacological characteristics. Mutations in CACNA1A are responsible for several inherited neurologic disorders including, familial hemiplegic migraine, episodic ataxia type2, and spinocerebellar ataxia type 6 epilepsy. Cav2.1 channels expressed in neurons are therapeutic targets in pain.

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