Human Cav3.2 Calcium Channel Cell Line

The human CACNA1H gene encodes the pore-forming subunit of Cav3.2, a voltage-gated T-type calcium channel. Mutations in CACNA1H have been linked to inherited neurologic diseases including idiopathic generalized and childhood absence epilepsies. Cav3.2 channels expressed in CNS neurons and non-neuronal tissues (sinoatrial node, atrioventricular node, kidney, liver, and vascular endothelium) are therapeutic targets in seizure, hypertension, angina, neuropathic pain, insomnia, and cancer.

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