Human FPRI Receptor Cell Line

The FPRI, FPRLI and FPRL2 receptors belongs to a family of receptors that all respond to N-formyl peptides. N-Formyl peptides are bacterial peptides which induce chemotaxis in neutrophils and other phagocytic cells to sites of bacterial infection. This cell line allows FPR1 to couple to the intracellular signaling pathway through Ga16, and should be useful for screening compounds for activity as modulators of host defense mechanisms against bacterial infection and in the regulation of inflammatory responses.

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