Human Mrg-X2 Receptor Cell Line

This receptor belongs to a family of 4 sensory neuron-specific G-protein coupled receptors that are expressed in small diameter primary sensory neurons and in several other tissues. Mrg-X2 is a Gi- and Gq-coupled receptor which is potently activated by cortistatin-14. Because of its expression in sensory neurons and because these sensory neurons transmit pain sensation, this receptor is of interest as a therapeutic targets for pain medications. This cell line, expressed in HEK293 cells with no other exogenous G proteins, displays a robust calcium response and will be useful as a drug discovery reagent.

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