Nicotinic receptors (nAChR) are acetylcholine-activated non-selective cation channels that mediate excitatory neurotransmission. The receptor-channels are configured as hetero- or homopentamers. Channels that contain α3 subunits typically have lower Ca2+ permeability compared to those containing α7 subunits. Therefore, α7 nAChRs are particularly important in regulation of Ca2+-dependent signalling pathways. Tissue distribution also differs with α3β4 receptors prominent in autonomic ganglia and α7 receptors widely distributed in the CNS.
Human Nicotinic Acetylcholine Receptor α7+RIC-3 Membranes
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