Orexin-A and orexin-B are peptides expressed in brain that have been implicated in controlling feeding behavior, energy homeostasis and sleep-wake cycle. These peptides exert their effects through two GPCRs, known as the orexin-1 and orexin-2 receptors, both of which are Gq/11-coupled.
Human OX1 Orexin Receptor Membranes
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