Protease-activated receptor-1 (PAR1) belongs to a four-member family of GPCRs that are activated by proteases (see Ossovskaya et al. for review). These proteases cleave a specific extracellular amino-terminal domain of the receptor to reveal a tethered ligand, which in turn activates the receptor which couples via Gq to release intracellular calcium (Nystedt, S. et al., 1995). PAR1 is expressed in platelets, vasculature, GI tract, CNS, lung, kidney, liver and heart. PAR1 is a relevant target for coronary thrombosis, inflammatory bowel disease and cancer.
Human PAR1 Protease-Activated Receptor Cell Line
For pricing information, detailed technical sheets, or to speak with one of our experts, please contact us at 1.877.CRIVER.1 (1.877.274.8371) or by using our online form.
Can't find what you are looking for? Contact us. We are always developing new cell lines and can work with you on custom projects.