Human PAR4 Protease-Activated Receptor Cell Line

Protease-activated receptor-4 (PAR4) belongs to a four-member family of GPCRs that are activated by proteases (see Ossovskaya et al. for review). These proteases cleave a specific extracellular amino-terminal domain of the receptor to reveal a tethered ligand, which in turn activates the receptor which couples via Gq to release intracellular calcium (Nystedt, S. et al., 1995). PAR4 is expressed in the vasculature, GI tract, leukocytes, lung and heart. PAR4 is a relevant target for coronary thromboses, inflammatory bowel disease and cancer.

Catalog Number

A609

Related Cell Lines

For pricing information, detailed technical sheets, or to speak with one of our experts, please contact us at 1.877.CRIVER.1 (1.877.274.8371) or by using our online form.

Can't find what you are looking for? Contact us. We are always developing new cell lines and can work with you on custom projects.

View All Cell Lines