TRPC4 (transient receptor potential channel, subtype C4) is a non-selective, calcium-permeable cation channel activated by GPCRs, via Gq-mediated phospholipase C stimulation and direct stimulation by Gi. The primary splice variant, TRPC4α contains cytosolic domain that inhibits activity of the channel at low cytosolic calcium concentrations, and activation of TRPC4α by physiological mechanisms requires simultaneous activation of Gq and Gi-coupled receptors. TRPC4 is highly expressed in renal cancer cell lines, and the natural product Englerin A directly activates TRPC4, which leads to selective cell death in TRPC4-expressing cells.
Human TRPC4α Transient Receptor Potential Channel Stable Cell Line
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