TRPC5 (transient receptor potential channel, subtype C5) is a non-selective, calcium-permeable cation channel activated by GPCRs, via either Gq-mediated phospholipase C stimulation or direct stimulation by Gi. Regions of the central nervous system such as hippocampus, amygdala and frontal cortex exhibit the highest expression levels of TRPC5, and the channel appears to regulate growth cone extension and axonal pathfinding. In cell-based assays for TRPC5 activity, the channel may be activated indirectly via stimulation of a GPCR coupled to phospholipase C. Alternatively, TRPC5 may be directly activated by a natural product, Englerin A.
Human TRPC5 Transient Receptor Potential Channel Stable Cell Line
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