Clariant Seminar 2019

We value the ongoing partnership we have with Clariant. Our dedicated team is ready to support you as you seek to develop innovative and sustainable solutions for your customers. Our scientists have already collaborated with your colleagues on many studies for Clariant. We are excited to continue to partner with you in your efforts, and delighted by this opportunity to share our insights with you.

The presentations in our recent seminar discussed our experiences in the various scientific areas, as well as updates on the current markets and the relevant regulatory guidelines.


Attendees in lecture hall at Charles River Presents: Finding the Right Alternative Model for Regulatory Testing.

In Vitro Metabolism
Mira Wenker, PhD., ERT, Section Head, Drug Metabolism and Pharmacokinetics

Developmental & Reproductive Toxicology
Manon Beekhuijzen, PhD., ERT, Head, Developmental and Reproductive Toxicology

Ecotoxicology and Higher Tier Fish Studies
Marcel Migchielsen, BSc., Head, Environmental Sciences


Mira Wenker, PhD., ERT | Section Head, Drug Metabolism and Pharmacokinetics

Mira Wenker manages both in vivo and in vitro DMPK studies for Charles River’s drug metabolism and pharmacodynamics group based in Den Bosch, The Netherlands. She has worked in the field of DMPK within contract research organizations for more than 15 years.

Manon Beekhuijzen, PhD., ERT | Head, Developmental and Reproductive Toxicology

Manon Beekhuijzen started as Study Director for developmental and reproductive toxicology (DART) studies at our Charles River Den Bosch facility in 1999. She was responsible for the set up all DART and juvenile studies at this site. She is now the section head of the DART department and is currently leading the nine DART study directors in Den Bosch. She is registered as European Toxicologist (ERT), president of the Dutch Society of Toxicology subgroup DART, and from 2015 to 2016, she was president of the European Teratology Society (ETS).

Marcel Migchielsen, BSc. | Head, Environmental Sciences

Marcel Migchielsen is Section Head of the Environmental Sciences department of Charles River’s Den Bosch facility. He has worked in the contract research industry for 25 years, and specializes in aquatic toxicity (short and long-term), biodegradation and terrestrial toxicity. He has extensive experience in the conduct and management of standard regulatory and custom-designed studies to support compound development in chemical, agrochemical and pharmaceutical industry sectors. He further has extensive experience with so-called difficult substances (e.g. mixtures, poorly soluble, unstable etc.) from the industrial chemical sector.

You may also be interested in the following resources which are available to access at your convenience:

Webinar replays

Extended One-Generation Reproductive Toxicity Study*

This webinar series discusses extended one-generation reproductive toxicology, and addresses the use of the EOGRTS globally within REACH and other industrial chemical legislation.

Part 1 – Strategies, Study Design and Regulatory Updates: OECD 421, 422, and 443
Part 2 – Assessment of Reproductive, Endocrine and Developmental Neurotoxicity on the OECD 443 Study
Part 3 – Development Immunotoxicity for the Extended One-Generation Reproductive Toxicity Study
Part 4 – Specialty Pathology Endpoints Used in the Extended One-Generation Reproductive Toxicity Study

* To access these resources, you must log in to The Source℠, our secure portal with exclusive content including information on large animal models, neonatal and juvenile toxicology, and historical control data. Please ask us for access if you are not already registered.

Industrial Chemicals: Adding Global Value to Your Registration Program

This webinar discusses how considering the requirements in well-regulated areas before starting testing could help establish the most cost- and time-effective program, and optimize your chemical’s market potential

eGuides | Download to your desktop

Global Registration eGuide

REACH eGuide

Scientific Posters

Optimisation of the Direct Peptide Reactivity Assay (DPRA) for poorly soluble substances

Non Animal Skin Sensitisation Testing Under REACH