Charles River designs and conducts GLP-compliant quantitative whole-body autoradiography (QWBA) programs integrated with our preclinical drug metabolism services. In addition to providing a quantitative measure of distribution, the high-resolution digital image obtained from a phosphorimager can be enlarged to provide greater depth and detail of distribution in the tissues or organ of interest.
MALDI-MSI (Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging) provides a label-free imaging alternative for the detection and localization of drugs and drug metabolites. Ideally suited to assessing the intra-organ distribution of drugs (and metabolites), MALDI-MSI can be successfully adapted to provide whole-body images in small rodent species. Furthermore, using proprietary software, quantitative data can be produced.
- Tissue distribution
- Target organ/tissue validation
- Correlation with histopathology
- Placental transfer
- Penetration of blood-brain barrier
- Tumor penetration
- Support of micronucleus test
- Human dosimetry calculations
- Dermal/ungual penetration
- Other beta or gamma emitters