Chemistry Guides Key Decisions

Discovery chemists guide key decisions by considering factors such as client intellectual property (IP) generation, compound stability for in vivo studies, solubility and other poor property issues, weak exposure in an animal, and off-target selectivity. These factors have been used to guide clients and allowed our clients to bring commercially successful therapies to patients in reduced timelines.

Charles River’s chemical discoveries are due to the experience of our scientists and processes put in place across all of our sites. Our translational integrated drug discovery approach enables an efficient  navigation of the early discovery process. Our discovery chemistry services project managers are scientists who expertly to coordinate in-house Charles River medicinal chemistry, synthetic chemistry, biology, structural biology, DMPK, in vivo pharmacology, and formulation teams. All teams are focused on the seamless orchestration towards the discovery of partner candidate compounds.

  • Highly experienced chemistry CRO team

    Together, the Charles River discovery chemistry services team is cited as inventors on over 350 patents and for partner organizations across a variety Our discovery chemistry services team has great success and vast experience in progressing small molecule drug discovery programs across a broad range of therapeutic areas and gene families. Our scientists are skilled in the design and synthesis of novel pharmacologically active compounds and understand the challenges facing modern drug discovery.

  • Track record of discovery chemistry

    Together, the Charles River discovery chemistry services team is cited as inventors on over 350 patents and for partner organizations across a variety of therapeutic areas. A high proportion of candidates have progressed to the clinic and our first co-invented drug, Belinostat, received marketing approval in 2015.

  • Flexible business models for discovery chemistry services

    Charles River medicinal chemists work with clients to progress programs quickly and efficiently during all points in the drug discovery workflow. In addition to stand-alone, fee-for-service pricing models, we offer fully integrated discovery chemistry services such as in-sourced chemistry collaborations where Charles River chemists are recognized as integral parts of our client’s chemistry departments.

We provide integrated drug discovery services spanning hit identification, hit-to-lead, and lead optimization, all complemented by synthetic, process, and scale-up chemistry, computer-aided drug design, structural biology, assay development and screening, and comprehensive ADME and PK profiling.

Question for our chemists?

Discovery Chemistry Services Frequently Asked Questions (FAQs)

  • Does Charles River provide in-house drug discovery chemistry consultants?

    Yes, Charles River offers many business models and we are committed to meeting clients needs. Some clients prefer not to recruit in-house chemists and so Charles River provides chemists provide on-site services.

  • Does Charles River provide fee-for-service chemistry services?

    Yes, we provide many business models including a fee-for-service model. Each client is different and we are a flexible chemistry CRO. In some clients have their own medicinal chemistry teams, but require additional chemists to quickly scale up. Some clients leverage Charles River discovery chemistry services a backup to their main series. In this case, we work with our partner’s in-house team to provide the diversity of thought.

  • How many candidates has Charles River progressed through to clinic?

    We are cited as inventors on over 350 patents and have identified 80 candidates for partner organizations across a variety of therapeutic areas. A high proportion of candidates have progressed to the clinic and our first co-invented drug, Belinostat, received marketing approval in 2015.

  • Does Charles River offer services other than discovery chemistry services?

    Yes, In addition to discovery services such as assay development and screening, pharmacology, ADME and integrated programs, Charles River provides post-discovery services such as safety assessment, biologics, research models, and microbial services. Charles River is proud to have worked on approximately 85% of the drugs approved by the FDA in 2018.