Center for Stroke and Dementia Research (CSD)
Join us on Thursday, 6th June 2019 from 14:00 to 16:00 at the Center for Stroke and Dementia Research (CSD), Room 8G U1 155, Feodor-Lynen-Strasse 17, 81377 München.
14:00 – 14:20 Registration
14:20 – 15:10 Expanding Our View Of Viruses And Bacteria In Our Laboratory Rodents By Next Generation Sequencing: A Pandora’s Box, or Research Necessity?
New technology has always played a role in improving the way we develop, monitor, and propagate our research models. In the last decade, Next generation sequencing (NGS), also known as massive parallel high density sequencing, has provided research labs with a relatively affordable way to obtain huge amounts of nucleic acid sequence data in a short period of time.
Over the last 10 years, NGS has dramatically contributed to every aspect of life science research – from oncology to rare genetic disorders. In the realm of laboratory animals, NGS has now given us new information, such as the impact of the microbiome on research outcomes or the discovery of new rodent viruses.
This presentation will provide a perspective of how NGS technology is being used to gain a better understanding of the microbiome’s impact on research, the limitations of attempts to reduce microbial drift, and advance pathogen discovery and identification.
Dr. Ken Henderson
Senior Director, Laboratory Services
15:10 – 16:00 Modern Paradigms in the Health Surveillance of Rodents
Traditionally, quarantine and routine health monitoring of rodents have relied on the use of bedding sentinel mice. Several studies by different researchers questioned the ability of sentinel mice to detect all pathogens via dirty bedding transfer, i.e., few agents were not successfully transferred to bedding sentinels, including adenovirus and pneumocystis.
Over the last decade, our laboratory has been investigating modern approaches to pathogen screening of laboratory rodents, including direct sampling and Exhaust Air Dust (EAD®) testing. EAD® health monitoring improves pathogen surveillance and reduces or eliminates the need for bedding sentinels.
The goal of this discussion is to review the impact of various rodent housing systems on health monitoring programs and to provide the means to maximize pathogen detection for each cage and rack type.
Dr. Rajeev Dhawan
Senior Director, BioAssay Services
P: +49 (0)9761 40666