Charles River & The Jackson Laboratory Seminar 2019


IGC - Instituto Gulbenkian de Ciência

Join us on Thursday, 26 September from 9:15 to 13:10 at the Ionians Auditorium IGC - Instituto Gulbenkian de Ciência - Rua da Quinta Grande, 6, 2780-156 Oeiras, Portugal.


Urte Jaeh (Dipl. Biol.)
EU Scientific Service Support Manager, Charles River

Agenda, September 26, Thursday, 2019

9:15 – 9:30     Registration and Welcome

9:30 – 10:30   Key Differences Among B6 Substrains: “Know your B6 Mouse and the Research Impact”

The C57BL/6 inbred mouse (B6) is the most commonly used research strain. This strain is the best characterized and the first to have its entire genome sequenced and the genetic background strain of choice for most targeted mutations and transgenics. The universal acceptance and demand for B6 mice has necessitated their production from multiple sources, introducing genetic and phenotypic variability that has important consequences for accurately interpreting and repeating research results. In this seminar, we will discuss the following topics:

  • A brief historical perspective on the development of B6 inbred mice and different substrains
  • Recent publications highlighting significant physiological and behavioral differences among different B6 inbred mice
  • The significance for control selection and experimental design
  • Key tips for avoiding common B6 research mistakes

10:45 – 11:45     Strategies to Minimize Genetic Drift and Maximize Experimental Reproducibility in Mouse Research

Reproducibility of results is the key element for our global research community. Genetic background is subject to genetic drift that may result in phenotypic drift over time. In this seminar, you will learn about the following topics:

  • The basis for genetic drift with case studies
  • Recognize genetic background of your mouse strain and the necessity to use the proper nomenclature
  • Selection of appropriate controls
  • Strategies to reduce genetic drift and increase experimental reproducibility

11:45 – 12:10     Coffee Break for all seminar participants

12:10 – 13:10     What’s in a Name? Understanding the Basics and Research Value of Mouse Nomenclature

Mouse nomenclature can be used to determine a strain’s genetic background, genetic modifications, who generated it, and who currently distributes it. Understanding mouse nomenclature enables you to select optimal mouse models and control strains for your research and also, to generate the most reliable and reproducible data. Join this seminar to learn about:

  • Interpreting the nomenclature of inbred, mutant, and genetically modified mouse strains
  • How quickly substrains develop and effect research results
  • The impact of genetic background on strain phenotypes
  • Considerations for selecting control mice


Carlos García de la Torre
Account Manager | Charles River
Mobile: +34 616 526 178
[email protected]