Charles River & The Jackson Laboratory Seminar 2020

Overview

IGMM – Institut de Genetique Moleculaire de Montpellier

Salle Phillippe Jeanteur
CNRS UMR 5535
1919 route de Mende
34293 Montpellier


This event has been postponed. It will be rescheduled. 


Friday, March 20, 2020

9:00 – 9:15     Registration and Welcome
 

9:15 – 10:15   Cutting Edge Human Disease Modeling Using NSG® Mice

Speaker: Elizabeth Axton, PhD
Senior Technical Information Scientist, The Jackson Laboratory

The immunodeficient NOD SCID gamma (NSG®) mouse strain enables human disease research that was previously impossible. In this seminar, we will explain how NSG® mice increase the efficiency and sophistication of mouse models of human disease in many important therapeutic areas. Join us as we discuss using NSG® mice to:

  • Create in vivo models that support the growth and integrity of the widest range of humans cells and tissues;
  • Perform the most efficient and reliable engraftment of human hematopoietic cells to date ("humanization");
  • Provide a platform for novel transgenic and gene-targeted mouse strains that further supports the growth and function of human tissues in vivo.


10:15 – 11:15  Key Differences Among B6 Substrains and Their Research Impact

Speaker: Elizabeth Axton, PhD
Senior Technical Information Scientist, The Jackson Laboratory

Selecting the C57BL/6 inbred mouse (B6) substrain for your research can be challenging. The genetic and phenotypic differences of the available B6 substrains directly impact the interpretation and reproducibility of research results. During this seminar, we will discuss considerations for choosing and using the most appropriate B6 substrain for your research needs. Join us to learn about:

  • The development of B6 inbred mice and emergence of different B6 substrains
  • Recent publications highlighting significant physiological and behavioral differences among them
  • The importance of selecting the best substrain to use as a control
  • Tips to avoid common research mistakes using B6 mice


11:15 – 11:30     Coffee Break
 

11:30 – 12:45     How to Refresh Your Transgenic Strain

Speaker: Jean Cozzi, PhD
Innovation Manager, Charles River

Most research is currently conducted on mouse inbred strains in controlled, sanitary environments. This approach, when correctly executed, eliminates strong in vivo variability, such as genetics and health status, allowing you to compare results obtained from experiments performed in any laboratory. To achieve this, you must have a strategy in place to manage your mouse colonies. This presentation will review successful strategies and their associated tools for researchers to prevent and correct common drifts from health and genetics standards.


12:45 – 13:30     Lunch
 

13:30 - 14:30      Maintaining a Static Microbiome Across Research Projects: Can It Be Done?

Speaker: Stéphanie Durand, PhD 
Diagnostic Scientist Veterinary and Professional Service, Charles River

As recent studies have demonstrated, microbiota are key biologic contributors to many aspects of mammalian physiology and behavior. As a result, their influence on research model phenotypes (and subsequent impact on study results) can be considerable. This seminar will answer some of the questions the biomedical science community has asked, including:

  • How can we define and create the precise microbiome consortium researchers need?
  • Once they are created, how can we avoid contamination, or "microbial drift"?
  • What can be done to monitor germ-free animals and those with a customized flora?


Contact

Emmanuelle Campigna
Business Development Manager | Charles River
Mobile: +33 633 20 33 53
[email protected]