Centro Nacional de Biotecnología (CNB)
This virtual event will be held on Microsoft Teams.
A few days after registering, you'll receive an Outlook Calendar invitation.
Wednesday, September 29
10h00 – 11h00
Genetic Drift – What it is and How to Minimize its Impact on Your Research
The phenotypes of genetically modified mouse strains depend on the genetic mutation and background. Genetic background is subject to genetic drift which may result in phenotypic drift over time. In this seminar, you will learn about the following topics:
- The basis for genetic drift
- Case studies demonstrating genetic drift and its effects on experimental results
- The Jackson Laboratory’s unique Genetic Stability Program to stop cumulative genetic drift
- Steps to ensure the long-term genetic and phenotypic stability of your mutant mice
Thursday, September 30
10h30 – 11h30
Genetics of Research Mice From Fiction to Facts
Inbred mice have historically been essential models for scientific research, and will continue to be so. Indeed, genetic standardization plays a key role in reducing variances within study populations, it facilitates both the monitoring of therapeutic efficacy, and reduces differences between studies in order to maximize reproducibility of results.
However, recent studies have revealed that a high proportion of inbred mouse lines are genetically heterogenous populations. Genotyping inconsistencies, genetic background pollution (even if subtle), and misinterpretation of genetic testing all lead to poor mouse model genetic standardization. This presentation will review how genetic background heterogeneity may arise within a colony, and what molecular testing approaches such as polymorphic markers analysis (SNPs and STRs) really tell us about mouse genetics.
Do you have questions? Would you like to discuss your project? Come and talk with Jean Cozzi!
Jean Cozzi, PhD
Innovation Manager, Genetically Engineered Models and Services Europe
Carlos García de la Torre
Account Manager | Charles River
Mobile: +34 616 526 178