Virtual Seminar

Charles River Presents: Immunology and Infection Assays to Advance Drug Discovery Poster Resources

Attendee at Immunology and Infection Assays to Advance Drug Discovery

This interactive event features eight simultaneous presentations spanning three distinct therapeutic areas including autoimmune diseases, vaccine and infectious diseases, and immuno-oncology and neuroinflammation. View the posters as well as submit your questions to our presenting experts below.

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Room 1: Autoimmune Diseases, PD, and Efficacy Models

Building a Translational Pathway Using Pharmacodynamic Models to Enable the Development of Cancer Immune TherapiesHenry Leonard, Senior Scientist, Charles River Discovery Research Services UK in Portishead

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Building an Immuno-oncology Targeted Translational Pathway Using Primary Human Myeloid CellsLauren Schewitz-Bowers, Manager, Cell Biology, Discovery Services, Charles River Discovery Research Services UK in Portishead

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The Animal Model of Systemic Lupus Erythematosus to Test Efficacy of Novel TherapeuticsManuela Cerina, PhD, Group Leader, Pharmacology, Charles River Discovery Research Services UK in Portishead

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Room 2: Vaccine and Infectious Diseases

Vaccine Development in the Discovery Space: Understanding the Key Players in the Immune Response to a Pathogen Helps Inform Vaccine DesignKate James, Microbiologist, Charles River Discovery Research Services UK in Portishead

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Efficacy of Ceftobiprole in a Murine Model of SepsisCharlotte Cumper, Senior Microbiologist, Charles River Discovery Research Services UK in Portishead

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Room 3: Immuno-Oncology and Neuroinflammation

In Vitro Tumour Killing Assays for Predicting Cellular Therapeutic EfficacyMatthew Boyton, Scientist, Charles River Discovery Research Services UK in Portishead

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A Translational Immuno-oncology Platform to Model T cell Activation and Tex Recovery in the Tumor MicroenvironmentLaura McMillan, M1 Manager, Cell Biology, Charles River Discovery Research Services UK in Portishead

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Characterization if the MOG35-55 Induced Experimental Autoimmune Encephalomyelitis (EAE) Model of MS in Mouse by Imaging, Behavior, Gene Expression Profiling and Neurofilament Light Chain (NfL) QuantificationAurelien Bunga, Senior Scientist (Neuroimmunologist), Charles River Discovery Research Services UK in Portishead

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Headshot of Henry Leonard


Henry Leonard
Senior Scientist
Charles River Discovery Research Services UK in Portishead

 

Henry obtained his Bachelor of Science in Biology from the University of Bristol, followed by a Masters in Cancer Research at the University of Birmingham. He later obtained his PhD in Cancer Immunology from the University of Southampton. Based on his experience working in two CRUK centers and Charles River, he has built a strong interest in T cell biology and translational research applications.


Headshot of Lauren Schewitz-Bowers


Lauren Schewitz-Bowers
Manager, Cell Biology, Discovery Services
Charles River Discovery Research Services UK in Portishead

 

Lauren Schewitz-Bowers received her PhD in ocular immunology from the University of Bristol where she focused on T cell and macrophage interactions within an autoimmune setting. Subsequently, she continued her postdoctoral research by focusing on immunotherapeutic target and biomarker discovery in line with one of the NIHR – Biomedical Research Centre’s strategic themes of personalizing medicine. She joined the Cell Biology team at Charles River Laboratories in 2019, bringing her knowledge of immunotherapy drug target development within an in vitro setting and oversees several pre-clinical drug discovery studies for multiple clients.

She completed her PhD studying monoclonal antibodies against influenza viruses at Babraham Institute Cambridge. Her work includes research on herpesviruses at Cambridge University and the University of Bristol, and modulating immune responses to viral infection.


Headshot of Manuela Cerina


Manuela Cerina, PhD
Group Leader, Pharmacology
Charles River Discovery Research Services UK in Portishead

 

After completing her PhD in neurophysiology and neuroscience from the University of Muenster, Germany, Manuela Cerina completed two postdoctoral appointments at the University Hospital of Muenster, in the Department of Neurology and Translational Neurology. Here, she focused on understanding the pathophysiology of autoimmune diseases like multiple sclerosis. As a senior scientist leading the Pharmacology team, she combines her experience with animal models of disease with expertise in neuroscience and immunology to oversee in vivo drug screenings in models of disease in the autoimmune therapeutic area.


Headshot of Kate James


Kate James
Microbiologist
Charles River Discovery Research Services UK in Portishead

 

A 2019 graduate of Biomedical Sciences from the University of Kent, Kate spent a year obtaining hands-on experience at a pharmaceutical company before joining Charles River in 2020.


Headshot of Charlotte Cumper


Charlotte Cumper
Senior Microbiologist
Charles River Discovery Research Services UK in Portishead

 

In 2012, Charlotte graduated from Cardiff University and joined KWS Biotest as a Microbiologist. She later transferred to Charles River in 2018 and is now a Senior Microbiologist involved in a range of both viral and bacterial projects.


Headshot of Matthew Boyton


Matthew Boyton
Scientist
Charles River Discovery Research Services UK in Portishead

 

Matthew joined Charles River in 2018 following the acquisition of KWS BioTest and focuses on developing immunological assays within the Cell Biology team.


Headshot of Laura McMillan


Laura McMillan
M1 Manager, Cell Biology
Charles River Discovery Research Services UK in Portishead

 

Laura joined Charles River in 2018 following her postdoctoral research in T cell signaling. She has a neuroscience background and remains fascinated by the interplay and parallels between the nervous system and the immune system. Since 2019 she has led a small team focusing on immuno-oncology and neuroinflammation research.


Headshot of Aurelien Bunga


Aurelien Bunga
Senior Scientist (Neuroimmunologist)
Charles River Discovery Research Services UK in Portishead

 

Dr. Aurelien Bunga received his Bachelor of Science in Biochemistry at the University of Leeds in 2013. He began his career as a research assistant gaining experience in molecular and cell biology techniques while investigating the role of Alzheimer's APP in iron homeostasis.

Dr. Bunga later received his PhD at Cardiff University in 2019. In his thesis work, he used human stem cell-derived models of microglia to study the role of microglia-enriched risk factors in Alzheimer's disease and of dysregulated immune pathways in the pathogenesis of Huntington's disease.

After completing his PhD, Dr. Bunga accepted a position as senior scientist at Charles River where he has worked on a number of neuroinflammation and immuno-oncology projects.