Charles River & The Jackson Laboratory Online Seminar Series


Four Presentations, Two Dates

This virtual event will be held on Microsoft Teams. A few days after registration, you will receive an Outlook Calendar invitation for the sessions you wish to attend.

Wednesday, 16 September, 2020

11:00 AM     Embryology Tools

Speaker: Jean Cozzi, PhD
Innovation Manager, Charles River Europe

Breeding transgenic mice and rats can bring many challenges regarding health status, breeding performance, and mitigating risk including genetic contamination and genetic drift. Join us as we will review the toolkits available to today's embryologists. These include cryopreservation, rederivation, line rescue, and others.

3:00 PM      Biosecurity: Identifying and Managing Critical Control Points

Speaker: Wairimu Gatome BVM MSc PhD Dip. ECLAM MRCVS
Manager, Veterinary and Training Services, Charles River

For a research animal facility, a solid biosecurity programme is not only a continuous process of risk management designed to prevent potential microbiological and genetic contamination, it also should limit impact should a situation occur. This presentation will review pathogen exclusion lists including agents of concern, sources of contamination (both internal and external), and the various control points for risk mitigation.

Wednesday, 23 September, 2020

11:00 AM      CRISPR*: The Good, The Bad, and The Ugly

Speaker: Jean Cozzi, PhD
Innovation Manager, Charles River

CRISPR/Cas9* has revolutionized the creation of complex mouse and rat models. Genome editing opportunities can seem infinite, but there are parameters that must be considered. This presentation will review the pros and cons of CRISPR* and other gene-editing techniques, as well as provide perspective on what is attainable (or not) with today's technology options.

*CRISPR/CAS9 used under licenses to granted and pending US and international patents from The Broad Institute and ERS Genomics Limited.

3:00 PM       Genetic Drift – What It Is and How to Minimize Its Impact on Your Research

Speaker: Nicola Wallis
Research Model Specialist, Charles River

Over multiple breeding generations, all inbred and genetically modified mouse strains are subject to genetic drift. As a result, the phenotypes associated with the underlying genetic background can also drift. Join us as we discuss the basis for genetic drift, case studies demonstrating genetic drift and its effects on experimental results, and steps that can be taken to limit its impact, including the patented Jackson Laboratory Genetic Stability Program (GSP).

Questions? Contact:

Samantha Taft, BSc (Hons)
Assoc Business Development Manager, RMS
Charles River, UK
M: +44 (0) 7805762912
[email protected]