11th Annual PEGS Europe: Protein & Antibody Engineering Summit

Date

Monday, November 18, 2019 - Friday, November 22, 2019

Location

Lisbon, Portugal
Attendees at the 11th Annual PEGS Europe: Protein & Antibody Engineering Summit

Overview

PEGS Europe is the largest European event covering all aspects of protein and antibody engineering. In 2018, more than 1,100 delegates from 36 countries, including 70% from pharma and biotech organizations, convened in beautiful Lisbon, Portugal to discuss the latest advances in protein and antibody engineering.

Charles River is pleased to support the annual summit in collaboration with our partner, Distributed Bio. We hope you’ll join us for our luncheon presentation as part of the meeting’s Engineering Stream.

Presentation

Thursday, November 21 | 12:15 p.m.

Computational Immuno-Engineering Therapeutics Against Hard Targets: Cracking into GPCR Antagonists & Blood-Brain Barrier | Sarah Ives, Principal Scientist & Director, Contract Research, Distributed Bio

Immune checkpoint inhibitors make attractive yet challenging targets for antibody discovery, where a therapeutic-ready monoclonal antibody can take years to be discovered and subsequently engineered. Here we describe a computational antibody library design that was optimized for both sequence diversity and engineering fitness through the analysis of thousands of human antibody repertoires. The technology enables routine discovery against previously challenging targets including GPCRs, pMHC complexes, and rare epitopes.

Poster Presentations

Wednesday, November 20 | 10:00 a.m. - 6:45 p.m.

First-in-Class Meets Best-in-Class: Rapid Antibody Discovery on Hard Targets Combined with Fine-Grained Engineering and Optimization
Sarah Ives1 and Gianpaolo Fogliatto2
1Principal Scientist & Director, Contract Research, Distributed Bio; 2Business Development, Charles River

A Novel Generalizable Solution for Enabling Bispecific Antibodies to Cross the Blood Brain Barrier
Chelsea Jones1 and Gianpaolo Fogliatto2
1Associate Scientist, Distributed Bio; 2Business Development, Charles River

Thursday, November 21 | 10:35 a.m. - 2:00 p.m.

First-in-Class Meets Best-in-Class: Rapid Antibody Discovery on Hard Targets Combined with Fine-Grained Engineering and Optimization
Sarah Ives1 and Gianpaolo Fogliatto2
1Principal Scientist & Director, Contract Research, Distributed Bio; 2Business Development, Charles River

A Novel Generalizable Solution for Enabling Bispecific Antibodies to Cross the Blood Brain Barrier
Chelsea Jones1 and Gianpaolo Fogliatto2
1Associate Scientist, Distributed Bio; 2Business Development, Charles River

In combination with our integrated drug discovery services, our partnership with Distributed Bio creates end-to-end support for therapeutic antibody discovery and development. Want to meet with one of our scientists in Lisbon? Send an email to [email protected].